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Merck
West Point, PA, United States (on-site)
2 days ago
Merck
North Wales, PA, United States (on-site)
4 days ago
Merck
REMOTE, United States (on-site)
4 days ago
Merck
Rahway, NJ, United States (on-site)
4 days ago
Merck
Boston, MA, United States (on-site)
4 days ago
Merck
South San Francisco, CA, United States (on-site)
4 days ago
Merck
New Jersey, NJ, United States (on-site)
4 days ago

Description

Job Description

Our Clinical Research and Pharmacovigilance team push the boundaries of global healthcare through research and innovation. Through clinical trials and surveillance, we ensure the safety and efficacy of our existing and pipeline products to produce safe, effective, innovative medicine.

Our Company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where our Company has codified its legacy for over a century. Our Company's success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Translational Medicine at our Company Research Labs is responsible for shepherding investigational drugs through a critical transition in the drug development process, working to translate the benchtop science of preclinical discovery into compounds ready for assessment in large clinical populations. We work closely with scientific, regulatory, statistical, and modelling colleagues across the organization to plan and execute the early clinical Phase 1 development of novel therapeutics. For our efforts supporting the neuroscience drug development pipeline, our closest collaborations are with groups based in West Point PA, Boston MA, and London UK. We are seeking a highly qualified individual for a position in our group. The preferred candidate will have expertise in Neuroscience/Neurology, but candidates with a strong background in clinical translational research and desire to work collaboratively across different therapeutic areas will also be considered.

Translational Medicine is specifically responsible for:

  • Contributing to the identification of novel targets by partnering with discovery research teams to bring a clinical perspective into the earliest stages of target identification and validation, and executing clinical studies to evaluate the relevance of potential targets to human disease in order to justify investment in full development, that can be bridged into full development
  • Development of biomarker strategies through cross-functional teams that provide line-of-sight from First-in-Human studies through clinical Proof-of-Concept. This includes Experimental Medicine studies to establish and/or validate biomarker platforms.
  • Development and execution of the early clinical development strategy for novel therapy programs from Preclinical Candidate approval through clinical Proof-of-Concept (Phase 2 Development and execution of clinical pharmacology strategies for late stage development programs from Proof-of-Concept (Phase 2a) through worldwide marketing application.


Success depends on the integrity, knowledge, imagination, creativity, skill, diversity and teamwork of the people in the group. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of the global team, you will collaborate with talented and dedicated colleagues in Translational Medicine, as well as Discovery Sciences and late stage Clinical Research while developing and expanding your career.

Individual will report directly to Neuroscience Therapeutic Lead of Translational Medicine.

Primary Responsibilities:
  • Key member of an early development team, providing leadership in designing and executing early clinical development strategy
  • Development and execution of early clinical strategy for novel therapeutics including authoring initial clinical and biomarker plans for Lead Optimization programs, early clinical development plans for Preclinical Candidate molecules, and clinical pharmacology studies for programs in Phases I through IV of development.
  • Development and execution of studies to validate clinical platforms utilizing established and novel biomarkers, including imaging, electrophysiological and behavioral responses to interrogate biological activity in humans.
  • Provide clinical expertise for identification and validation of novel targets, including the design of preclinical and/or clinical pharmacology experiments to validate targets and/or pathways
  • Safe and timely execution of Phase I studies; close collaboration with internal and external clinical study support staff and scientists (including discovery research, biostatistics, drug metabolism, modeling and simulation, regulatory affairs, and global clinical trials operations)
  • Provide clinical pharmacology support for programs through the worldwide marketing application filing including supportive registration documents and presentations
  • Provide clear, timely communication and interpretation of study results to therapeutic area governance, functional area experts and development review committees.
  • Contribute to assessment of internal and external opportunities identified by Business Development and Licensing
  • Interface broadly with key functions including Discovery Sciences, Preclinical Pharmacology, Pharmaceutical Sciences, Toxicology, Translational Biomarkers, Translational Medicine Operations, Translational Medicine-EU, Drug Metabolism/Modeling & Simulation, Regulatory Affairs, and late stage Clinical Research throughout sites in the USA, UK and Belgium.


Education Minimum Requirements:
  • MD or MD/PhD; or
  • PhD/PharmD; at least 10 years of drug development experience to include preclinical pharmacology, biomarker validation and development, and team management


Required Experience and Skills:
  • Proven track record in clinical medicine or clinical research, and background in biomedical research.
  • Demonstrated record of scientific scholarship and achievement. Neuroscience expertise preferred, but a track record of excellence and a willingness to work collaboratively across different therapeutic areas with an emphasis on neuroscience drug development will be considered.
  • Strong interpersonal, writing and presentation skills, as well as the ability to function in a team environment are essential.
  • Board Certification or Eligibility (MD and MD/PhD) preferred
  • Prior specific experience in clinical research and prior publication preferably with experience in the area of basic, translational research and experience with early clinical development and patient care


We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we "follow the science" that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are ...

We are known as Merck & Co., Inc., Rahway, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for ...

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us-and start making your impact today.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

New hires in office-based roles in the US & Puerto Rico will be required, subject to applicable law, to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption to this vaccination requirement that can be accommodated without an undue burden to the operation. However, subject to applicable law, employees working in roles that the Company determines require routine collaboration with external stakeholders, such as employees in health services, customer facing commercial, or research based roles, will be required to be fully vaccinated as a condition of employment.

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Poster

EEOC GINA Supplement

OFCCP EEO Supplement

Pay Transparency Nondiscrimination

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Residents of Colorado:

Click here to request this role's pay range.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:
Regular

Relocation:
Domestic

VISA Sponsorship:
No

Travel Requirements:
25%

Flexible Work Arrangements:

Shift:

Valid Driving License:

Hazardous Material(s):

Number of Openings:
1

Requisition ID:R183711

Job Information

  • Job ID: 65863498
  • Workplace Type: On-Site
  • Location:
    Rahway, New Jersey, United States
  • Position Title: Senior Principal Scientist/Principal Scientist Translational Medicine - Neuroscience
  • Company Name For Job: Merck
  • Job Function: Assistant Director of Pharmacy
  • Job Type: Full-Time
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